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phase by runs of activity in motor units Why cramps should be painful is not known; probably the demands of the overactive muscle exceed metabolic supply, causing a relative ischemia and accumulation of metabolites Overwork of muscle with or without impairment of circulation is also painful Between cramps, the muscles are normal clinically and electromyographically Cramps are known to increase in frequency under certain conditions and with certain diseases They are frequent during pregnancy for reasons not fully understood Dehydration and sweating predispose to cramping and are a constant threat to athletes, who try to prevent them by ingesting electrolyte solutions Exertional cramps are frequent in motor system disease and hypothyroidism and less so in chronic polyneuropathies Patients undergoing hemodialysis are subject to cramps, which can be suppressed by intravenous hypertonic saline or hypertonic glucose Rapid rehydration after dehydration is another provocative factor. asp.net barcode font . 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Focal cramping occurs after partial nerve or root injury and with diseases involving anterior horn cells In one such condition, the calf muscle on one side is subject to severe recurrent cramps after decompression of the S1 root in lumbar disc disease; in extreme cases, the muscle hypertrophies The mechanism of muscle cramping is obscure In a number of cases with exercise-induced stiffness and muscle pain, sometimes progressing to cramp, below-normal levels of myoadenylate deaminase have been found The signi cance of this observation is uncertain This enzyme, which is present in high concentration in muscle, is thought to function primarily during aerobic exercise and facilitate the regeneration of adenosine triphosphate from adenosine diphosphate through the action of adenylate kinase Others assert that low levels of this enzyme are not speci c, occurring in such unrelated disorders as hypokalemic periodic paralysis and spinal muscular atrophy (see Layzer for details). asp.net barcode label printing ASP . 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